Statins are highly effective and widely prescribed cholesterol lowering drugs.However, statins cross the blood-brain barrier and decrease neural cholesterol in Push Button Switch animal models, raising concern that long-term statin use may impact cholesterol-dependent structures and functions in the brain.Cholesterol is a fundamental component of c
Vascular calcification is prominent in patients with chronic kidney disease (CKD) and is a strong predictor of Mountaineering - Homme - Skis cardiovascular mortality in the CKD population.However, the mechanism underlying CKD-associated vascular calcification remains unclear.To identify potential therapeutic targets, a 5/6 nephrectomy rat model was
Abstract Background The ubiquitous LysM motif recognizes peptidoglycan, chitooligosaccharides (chitin) and, presumably, other structurally-related oligosaccharides.LysM-containing proteins were first shown to be involved in bacterial cell wall degradation and, more recently, were implicated in perceiving chitin (one of the established pathogen-asso
In this article, we will investigate a retarded van der Pol-Duffing oscillator with Yerba Mate multiple delays.At first, we will find conditions for which Bogdanov-Takens (B-T) bifurcation occurs around the trivial equilibrium of the proposed system.The center manifold theory has been used to extract second order normal form of the B-T bifurcation.